State Key Laboratory of Microbial Technology, Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, The School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, China.
State Key Laboratory of Microbial Technology, Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, The School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, China.
Cell Immunol. 2019 Jun;340:103915. doi: 10.1016/j.cellimm.2019.04.003. Epub 2019 Apr 12.
During viral infection, the innate immune system represents the first defense line of the human body. The pathogen associated molecular patterns (PAMPs) from the viruses are recognized by pattern recognition receptors (PRRs) of the host cell, especially from those of the immune cells. Sensing of PAMPs by PRRs elicits an elegant signal transduction system, ultimately leading to the production of type I interferons (IFNs) and proinflammatory cytokines. Ubiquitination, with its versatile functions, plays a central role in modulating almost every single step of this signaling cascade. Ubiquitin ligases, which catalyze different types of ubiquitination correlating with multiple functions, are the key participant in fine-tuning antiviral signal transduction. In this review, we focus on summarizing the ubiquitin ligases that regulate the key signaling molecules in antiviral innate immunity.
在病毒感染期间，先天免疫系统是人体的第一道防线。病毒的病原体相关分子模式（PAMPs）被宿主细胞的模式识别受体（PRRs）识别，特别是那些免疫细胞的 PRRs。PRRs 对 PAMPs 的感应引发了一个优雅的信号转导系统，最终导致 I 型干扰素（IFNs）和促炎细胞因子的产生。泛素化具有多种功能，在调节信号转导级联反应的几乎每一个步骤中都起着核心作用。泛素连接酶，其催化与多种功能相关的不同类型的泛素化，是精细调节抗病毒信号转导的关键参与者。在这篇综述中，我们重点总结了调节抗病毒先天免疫中关键信号分子的泛素连接酶。
