State Key Laboratory of Microbial Technology, Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, the School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
State Key Laboratory of Microbial Technology, Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, the School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Adv Immunol. 2020;145:95-128. doi: 10.1016/bs.ai.2019.11.004. Epub 2019 Dec 9.
The innate immune system represents the first defense line of the host following viral infection. The infection triggers the recognition of pathogen-associated molecular patterns (PAMPs) from the viruses by pattern recognition receptors (PRRs) of the host cell. The interaction between viral PAMPs and PRRs evokes a sophisticated signal transduction system and eventually promotes the expression of type I interferons (IFNs) and proinflammatory cytokines. Ubiquitination plays an indispensable role in fine-tuning almost every single step of this signaling cascade given on its versatile functions. Ubiquitin ligases and deubiquitinases (DUBs), which cooperatively and accurately regulate the dynamic and reversible ubiquitination process, are the master regulators of antiviral signaling. In this review, we concentrate on summarizing the ubiquitin ligases and DUBs that modulate the central signaling molecules in antiviral innate immunity. Especially, we emphasize the ones that were identified by the immunologists from China.
固有免疫系统是宿主在病毒感染后形成的第一道防线。感染会触发宿主细胞模式识别受体（PRR）识别病毒的病原体相关分子模式（PAMP）。病毒 PAMP 和 PRR 的相互作用会引发复杂的信号转导系统，最终促进 I 型干扰素（IFN）和促炎细胞因子的表达。鉴于其多功能性，泛素化在精细调节这一信号级联反应的几乎每一个步骤中都起着不可或缺的作用。泛素连接酶和去泛素化酶（DUBs）协同并精确地调节动态和可逆的泛素化过程，是抗病毒信号的主要调节因子。在这篇综述中，我们集中总结了调节抗病毒固有免疫中中心信号分子的泛素连接酶和 DUBs。特别是，我们强调了那些被中国免疫学家发现的酶。
