Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Université Libre de Bruxelles, Bruxelles, Belgium; Psy Pluriel Centre Européen de Psychologie Médicale, Bruxelles, Belgium.
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30;94:109638. doi: 10.1016/j.pnpbp.2019.109638. Epub 2019 May 2.
The major aim of this multicenter study of the European Group for the Study of Resistant Depression (GSRD) was to elucidate associations between major depressive disorder (MDD) and comorbid diabetes.
Demographic and clinical information of 1410 patients with a primary MDD diagnosis according to DSM-IV were retrieved cross-sectionally between 2012 and 2016. By applying descriptive statistics, analyses of covariance (ANCOVA) and binary logistic regression analyses, a comparison between patient characteristics with and without comorbid diabetes was performed.
The point prevalence rate for comorbid diabetes across MDD patients was 6%. Individuals with MDD + comorbid diabetes were significantly older, heavier, more likely to be inpatient and diagnosed with additional comorbid chronic somatic diseases. In addition, current suicide risk was significantly increased and melancholic features were more likely pronounced. In general, patients in the MDD + diabetes group received a combination therapy with at least one additional antidepressant rather than various other augmentation strategies.
Our analyses depict a lower prevalence rate of diabetes in MDD patients than previous studies. However, in light of the prevalence of diabetes in the geographical area of the study, we found an increased risk for individuals with depression compared to the general population. Current suicide risk is markedly elevated and has to be thoroughly assessed in every patient with comorbid diabetes. Depression severity and treatment response remained unaffected by concurrent diabetes in MDD.
这项欧洲耐药性抑郁症研究组（GSRD）的多中心研究的主要目的是阐明重性抑郁障碍（MDD）与合并糖尿病之间的关联。
2012 年至 2016 年期间，我们横向收集了 1410 名符合 DSM-IV 标准的原发性 MDD 诊断患者的人口统计学和临床信息。通过应用描述性统计、协方差分析（ANCOVA）和二元逻辑回归分析，比较了伴或不伴合并糖尿病的患者特征。
MDD 患者中合并糖尿病的现患率为 6%。患有 MDD+合并糖尿病的个体明显年龄更大、体重更重、更有可能住院和诊断出其他合并的慢性躯体疾病。此外，当前自杀风险显著增加，且更有可能出现忧郁特征。一般来说，MDD+糖尿病组的患者接受了至少一种额外抗抑郁药的联合治疗，而不是各种其他增效策略。
与之前的研究相比，我们的分析显示 MDD 患者中糖尿病的患病率较低。然而，鉴于研究地区的糖尿病流行情况，我们发现与普通人群相比，抑郁症患者的风险增加。当前的自杀风险明显升高，在每例合并糖尿病的患者中都必须进行彻底评估。在 MDD 中，抑郁严重程度和治疗反应不受合并糖尿病的影响。
