Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Sport Science Research Institute of Iran (SSRI)|, Tehran, Iran.
Neurol Sci. 2019 Sep;40(9):1849-1854. doi: 10.1007/s10072-019-03892-6. Epub 2019 May 4.
In this study, we aimed to determine the difference of motor reaction time and accuracy between the patients with moderate multiple sclerosis (MS) and healthy subjects and to determine whether a specified cognitive-motor training can improve the speed and accuracy of information processing in patients with MS. A total of 205 patients (30% males) and 276 age-/gender-matched healthy subjects (31% males) were included in the study. Furthermore, using a stratified randomization method, patients with MS were randomly assigned to one of two groups: active information processing training (AIPT) (n = 49) or post-control (n = 55). The AIPT group was asked to complete a computerized visual-manual training program and the post-control group asked to complete the same task without an increase in difficulty. Before and after the intervention phase, the simple, choice, and semantic reaction times and accuracies of all participants were evaluated using the VLS measurement battery. Our results demonstrated that the case and control group were significantly different in terms of the simple, choice, and semantic motor reaction times and accuracies. Compared with the pre-intervention phase, the AIPT and control group's performances in the post-intervention phase were considerably improved in simple, choice, and semantic motor reaction times and choice and semantic motor reaction accuracies. The results also showed that the AIPT group performed significantly better than the post-control group in terms of simple and choice motor reaction times. We showed the positive effects of training on the performance of patients with MS in motor reaction time and accuracy.
在这项研究中，我们旨在确定中度多发性硬化症（MS）患者与健康受试者之间的运动反应时间和准确性差异，并确定特定的认知运动训练是否可以提高 MS 患者的信息处理速度和准确性。共有 205 名患者（30%为男性）和 276 名年龄/性别匹配的健康受试者（31%为男性）纳入研究。此外，我们采用分层随机化方法，将 MS 患者随机分为两组：主动信息处理训练（AIPT）组（n=49）和后对照组（n=55）。AIPT 组被要求完成计算机化的视觉-手动训练计划，而后对照组被要求在不增加难度的情况下完成相同的任务。在干预阶段前后，使用 VLS 测量电池评估所有参与者的简单、选择和语义运动反应时间和准确性。我们的研究结果表明，病例组和对照组在简单、选择和语义运动反应时间和准确性方面存在显著差异。与干预前阶段相比，AIPT 组和后对照组在干预后阶段的简单、选择和语义运动反应时间以及选择和语义运动反应准确性方面的表现都有了显著提高。结果还表明，AIPT 组在简单和选择运动反应时间方面的表现明显优于后对照组。我们证明了训练对 MS 患者运动反应时间和准确性的积极影响。
