[汉族原发性高血压患者中STK39基因多态性与氢氯噻嗪反应的关联]

[Association of STK39 gene polymorphism with response to hydrochlorothiazide among ethnic Han Chinese with essential hypertension].

作者信息

Hou Wenjing, Liu Min, Yu Shuhua, Wang Xiaofei, Du Hongyang, Zhou Lijuan, Cao Wei

机构信息

Translational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, China. Email:

Department of Hypertension, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, China.

出版信息

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2019 Jun 10;36(6):639-644. doi: 10.3760/cma.j.issn.1003-9406.2019.06.028.

DOI:10.3760/cma.j.issn.1003-9406.2019.06.028

PMID:31055826

Abstract

OBJECTIVE

To assess the association of single nucleotide polymorphisms (SNPs) of STK39 gene with response to hydrochlorothiazide among ethnic Han Chinese patients with essential hypertension.

METHODS

In total 118 patients with essential hypertension were recruited. All participants had received six weeks of treatment with hydrochlorothiazide 25 mg daily. Blood pressure (BP) and heart rate (HR) were measurement every 2 weeks. Genotypes of STK39 rs3754777 and rs6749447 were determined using a SNaPshot technique.

RESULTS

A significant difference was found in ΔSBP between individuals with rs3754777 CC, CT and TT and those with rs3754777 CC and CT-TT (P<0.05). A significant difference was also detected in ΔDBP between those with rs3754777 CC and CT-TT (P<0.05). No significant difference was found in ΔSBP and ΔDBP between individuals with STK39 rs6749447 GG, GT and TT (all P>0.05). Relative risk analysis showed that STK39 rs3754777 was significantly associated with BP response to hydrochlorothiazide (OR=0.416, 95%CI=0.189-0.918, P<0.05).

CONCLUSION

Polymorphisms of STK39 rs3754777 may be associated with BP response to hydrochlorothiazide among ethnic Han Chinese with essential hypertension.

摘要

目的

评估汉族原发性高血压患者中STK39基因单核苷酸多态性（SNP）与氢氯噻嗪反应之间的关联。

方法

共招募了118例原发性高血压患者。所有参与者均接受了为期六周的每日25毫克氢氯噻嗪治疗。每2周测量一次血压（BP）和心率（HR）。使用SNaPshot技术测定STK39 rs3754777和rs6749447的基因型。

结果

rs3754777基因型为CC、CT和TT的个体与rs3754777基因型为CC以及CT-TT的个体之间，在收缩压变化值（ΔSBP）上存在显著差异（P<0.05）。rs3754777基因型为CC和CT-TT的个体之间，在舒张压变化值（ΔDBP）上也检测到显著差异（P<0.05）。STK39 rs6749447基因型为GG、GT和TT个体之间，在ΔSBP和ΔDBP上均未发现显著差异（所有P>0.05）。相对风险分析表明，STK39 rs3754777与氢氯噻嗪的血压反应显著相关（OR=0.416，95%CI=0.189-0.918，P<0.05）。