表皮生长因子对人羊膜细胞花生四烯酸代谢的作用。
Epidermal growth factor actions on arachidonic acid metabolism in human amnion cells.
作者信息
Mitchell M D
出版信息
Biochim Biophys Acta. 1987 Apr 22;928(2):240-2. doi: 10.1016/0167-4889(87)90127-3.
PMID:3105596
Abstract
Epidermal growth factor (EGF) from human and murine sources increased prostaglandin E2 production by human amnion cells. An anti-EGF receptor monoclonal antibody abolished this stimulatory action of EGF and reduced the basal rate of amnion prostaglandin E2 biosynthesis. The rates of formation of arachidonate lipoxygenase products were also enhanced by EGF.
摘要
来自人和小鼠的表皮生长因子（EGF）可增加人羊膜细胞中前列腺素E2的产生。一种抗EGF受体单克隆抗体消除了EGF的这种刺激作用，并降低了羊膜前列腺素E2生物合成的基础速率。EGF还提高了花生四烯酸脂氧合酶产物的形成速率。
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