Emergency Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China; Hubei Province Academy of Traditional Chinese Medicine, Wuhan, China.
Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
Clin Nutr. 2020 Mar;39(3):893-900. doi: 10.1016/j.clnu.2019.03.029. Epub 2019 Mar 28.
Obesity and arterial stiffness are both independently associated with cardiovascular risk. New anthropometric indices can better reflect abdominal obesity than traditional anthropometric indices. Thus, we hypothesized that compared with conventional parameters, these newly developed anthropometric parameters were more accurate to identify arterial stiffness among overweight and obesity population.
Cross-sectional data on socio-demographic, lifestyle, clinical characteristics and biochemical measurements were collected for 1442 Chinese obese and overweight adults. Six anthropometric indices including a body shape index (ABSI), body mass index (BMI), ABSI combined with BMI, body roundness index (BRI), waist circumference and waist-to-hip ratio were calculated. Carotid-femoral pulse wave velocity (cf-PWV) was detected in all subjects. Meanwhile, visceral fat area (VFA) was quantificationally measured by CT. Partial Spearman correlation coefficients were used to clarify the association between anthropometric measures with cf-PWV. Logistic regression analyses were used to identify to the association between anthropometric measures and arterial stiffness.
After adjusting for covariates, BRI had the strongest correlation with cf-PWV and VFA in all anthropometric indices. Multivariate regression analysis showed VFA (β = 0.322, p < 0.001) and BRI (β = 0.307, p < 0.001) remained independently associated with cf-PWV. BRI had a highest odds ratios in all anthropometric indices (OR = 1.543, p < 0.001). ABSI only displayed a weak correlation with arterial stiffness. Meanwhile, BRI had the highest area under curve for abnormal cf-PWV, and the optimum cutoff value was a BRI ≥5.4.
BRI was found to have a close relationship with arterial stiffness in overweight and obesity people. However, ABSI was weakly correlated with arterial stiffness, but not better than traditional anthropometric indices.
肥胖和动脉僵硬均与心血管风险独立相关。新的人体测量指标比传统人体测量指标能更好地反映腹部肥胖。因此，我们假设与传统参数相比，这些新开发的人体测量参数在超重和肥胖人群中识别动脉僵硬更为准确。
本横断面研究共纳入 1442 例中国超重和肥胖成年人，收集了他们的社会人口统计学、生活方式、临床特征和生化测量等数据。计算了 6 个人体测量指标，包括体脂指数（ABSI）、体重指数（BMI）、ABSI 与 BMI 的结合、体圆度指数（BRI）、腰围和腰臀比。所有受试者均检测了颈股脉搏波速度（cf-PWV）。同时，通过 CT 定量测量内脏脂肪面积（VFA）。采用偏相关系数分析人体测量指标与 cf-PWV 的相关性。采用 Logistic 回归分析确定人体测量指标与动脉僵硬的关系。
在校正协变量后，BRI 与 cf-PWV 和 VFA 的相关性在所有人体测量指标中最强。多变量回归分析显示，VFA（β=0.322，p<0.001）和 BRI（β=0.307，p<0.001）与 cf-PWV 独立相关。BRI 在所有人体测量指标中的比值比最高（OR=1.543，p<0.001）。ABSI 仅与动脉僵硬呈弱相关。同时，BRI 对异常 cf-PWV 的曲线下面积最高，最佳截断值为 BRI≥5.4。
BRI 与超重和肥胖人群的动脉僵硬密切相关。然而，ABSI 与动脉僵硬相关性较弱，但并不优于传统的人体测量指标。
