比较两种新的人体测量学指数与经典肥胖指数在中国成年人中识别动脉僵硬度的能力。

Comparison of the ability to identify arterial stiffness between two new anthropometric indices and classical obesity indices in Chinese adults.

机构信息

Department of General Practice, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Department of Infectious Disease and Hepatopathy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

出版信息

Atherosclerosis. 2017 Aug;263:263-271. doi: 10.1016/j.atherosclerosis.2017.06.031. Epub 2017 Jun 16.

DOI:10.1016/j.atherosclerosis.2017.06.031

PMID:28704699

Abstract

BACKGROUND AND AIMS

The association between anthropometric indices of body composition and arterial stiffness is inconclusive. The objective of this study was to examine the predictive ability of two new obesity indices: a body shape index (ABSI), and a body roundness index (BRI), for the identification of arterial stiffness among Chinese adults, as well as to compare the relative strength of association between the anthropometric indices and arterial stiffness.

METHODS

A total of 10,197 subjects were recruited in this cross-sectional study. We tested the association between anthropometric indices (body mass index [BMI], waist circumference [WC], waist-height-ratio [WHtR], ABSI and BRI) and brachial-ankle pulse wave velocity (PWV). Receiver operating characteristic curve and area under curve (AUC) were employed to evaluate the predictive value of the anthropometric indices for identification of arterial stiffness.

RESULTS

After adjusting for confounding variables, BRI (linear regression: 0.112; AUC: 0.726; OR: 1.228 for female and linear regression: 0.047; AUC: 0.631; OR: 1.173 for male) exhibited a more powerful predictive ability of arterial stiffness than ABSI (linear regression: 0.110; AUC: 0.674; OR: 1.315 for female and linear regression: 0.058; AUC: 0.610; OR: 1.150 for male) and WC (linear regression: 0.078; AUC: 0.699; logistic regression: negative for female and linear regression: negative; AUC: 0.593; logistic regression: negative for male) while having a similar predictive value to that of WHtR (linear regression: 0.113; AUC: 0.726; OR: 1.228 for female and linear regression: 0.047; AUC: 0.631; OR: 1.185 for male) among both sexes. BMI (linear and logistic regression: negative; AUC: 0.660 for female and 0.568 for male) had the lowest predictive power in both sex categories. The optimal cut-off of WHtR for detecting arterial stiffness was 0.49 in females and 0.53 in males, that of BRI was 3.19 in females and 3.89 in males.

CONCLUSIONS

WHtR, ABSI and BRI were significantly associated with arterial stiffness. BRI and WHtR, rather than ABSI, showed superior predictive abilities for arterial stiffness in both sexes.

摘要

背景与目的

人体成分的人体测量指数与动脉僵硬度之间的关系尚无定论。本研究的目的是检验两种新的肥胖指数（身体形状指数[ABSI]和身体圆润度指数[BRI]）在识别中国成年人动脉僵硬度方面的预测能力，并比较这些人体测量指数与动脉僵硬度之间关联的相对强度。

方法

本横断面研究共纳入 10197 名受试者。我们检测了人体测量指数（体重指数[BMI]、腰围[WC]、腰高比[WHtR]、ABSI 和 BRI）与肱踝脉搏波速度（PWV）之间的关联。采用受试者工作特征曲线和曲线下面积（AUC）评估人体测量指数对动脉僵硬度的识别能力。

结果

在校正混杂变量后，BRI（线性回归：0.112；AUC：0.726；OR：1.228，女性；线性回归：0.047；AUC：0.631；OR：1.173，男性）与 ABSI（线性回归：0.110；AUC：0.674；OR：1.315，女性；线性回归：0.058；AUC：0.610；OR：1.150，男性）和 WC（线性回归：0.078；AUC：0.699；logistic 回归：女性为负；线性回归：负；AUC：0.593；logistic 回归：男性为负）相比，对动脉僵硬度的预测能力更强，而与 WHtR（线性回归：0.113；AUC：0.726；OR：1.228，女性；线性回归：0.047；AUC：0.631；OR：1.185，男性）在两性中的预测值相似。BMI（线性和 logistic 回归：负；AUC：女性 0.660，男性 0.568）在两性中的预测能力最低。女性检测动脉僵硬度的最佳 WHtR 截断值为 0.49，男性为 0.53；BRI 的最佳截断值为女性 3.19，男性 3.89。