尿酸与阿尔茨海默病和血管性痴呆的风险：一项基于人群的研究。
Urate and risk of Alzheimer's disease and vascular dementia: A population-based study.
机构信息
Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
出版信息
Alzheimers Dement. 2019 Jun;15(6):754-763. doi: 10.1016/j.jalz.2019.01.014. Epub 2019 May 2.
INTRODUCTION
Low serum urate (sU) has been suggested to increase the risk of dementia since a reduction might impair antioxidant capacity. On the other hand, high sU is associated with increased cardiovascular risk which might increase the risk of dementia, especially for vascular dementia.
METHODS
In 1968-1969, a population-based sample of 1462 women aged 38 to 60 years was examined and were followed up over 44 years (mean 33.1 years). We examined whether sU (determined in 1968-1969 and 1992-1994) is associated with risk of late-life dementia.
RESULTS
During 44 years of follow-up, a higher sU (per standard deviation of 76.5 μmol/L) was associated with lower risk for dementia (n = 320; hazard ratio [HR] 0.81; confidence interval [CI] 0.72-0.91), Alzheimer's disease (n = 152; HR 0.78; CI 0.66-0.91), and vascular dementia (n = 52; HR 0.66; CI 0.47-0.94).
DISCUSSION
Our findings support the hypothesis that sU has a protective role in the development of dementia, regardless of dementia subtype. This may have important implications in the treatment of dementia and treatment goals for hyperuricemia in patients with gout.
简介
低血清尿酸（sU）被认为会增加痴呆风险，因为尿酸降低可能会损害抗氧化能力。另一方面，高 sU 与心血管风险增加有关，这可能会增加痴呆风险，尤其是血管性痴呆。
方法
1968-1969 年，对 1462 名年龄在 38 至 60 岁的女性进行了基于人群的样本检查，并进行了 44 年的随访（平均随访 33.1 年）。我们研究了 1968-1969 年和 1992-1994 年测定的 sU 是否与晚年痴呆风险相关。
结果
在 44 年的随访期间，较高的 sU（每 76.5 μmol/L 的标准差）与痴呆（n=320；风险比 [HR] 0.81；置信区间 [CI] 0.72-0.91）、阿尔茨海默病（n=152；HR 0.78；CI 0.66-0.91）和血管性痴呆（n=52；HR 0.66；CI 0.47-0.94）的风险降低相关。
讨论
我们的研究结果支持这样的假设，即 sU 在痴呆的发展中具有保护作用，无论痴呆的亚型如何。这对于痴呆的治疗以及痛风患者高尿酸血症的治疗目标可能具有重要意义。
Zotero 插件