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[肠道康复计划对短肠综合征患者的疗效]

[Efficacy of the intestinal rehabilitation program in patients with short bowel syndrome].

作者信息

Rodríguez Iglesias P, Domènech Tárreg A B, Driller C, Mangas Álvarez L, Vila Carbó J J

机构信息

Servicio de Cirugía Pediátrica. Hospital Universitari i Politècnic la Fe. Valencia.

出版信息

Cir Pediatr. 2019 Apr 22;32(2):74-80.

Abstract

INTRODUCTION

In recent decades, intestinal rehabilitation programs, advances in parenteral nutrition (PN) and intestinal lengthening techniques have improved the results of patients with short bowel syndrome (SBS).

OBJECTIVE

To evaluate the growth, the independence of PN and the survival of patients with SBS diagnosed in the last 12 years.

MATERIAL AND METHOD

Retrospective review between the years 2007-2016. Defining SBS as the inability of the intestine to provide complete absorption via the enteral route being necessary PN. A multivariate analysis was performed to assess the prognostic factors regarding the autonomy of the NE controlled by Cox regression: ileocecal valve presence (qualitative variable: yes/no), small intestine length and gestational age (both quantitative variables).

RESULTS

18 patients were evaluated. The most frequent causes of SBS: necrotizing enterocolitis (6, 33.3%), jejunal atresia and Hirschsprung (4 cases each pathology, 22.2%) and others (4). The average intestinal length was 51.17 cm at diagnosis, 72.2% lacked an ileocecal valve. The mean PN at the start was 115.8 hours / week, currently: 56.9. The 22.2% achieved complete enteral nutrition (CEN) after an average time of 4.62 years. Serial transverse enteroplasty was performed in 3 patients.The presence of an ileocecal valve was a protective factor to achieve CEN (p<0.018). In contrast, intestinal length and gestational age were not significant. After a follow-up of 5.38 years (3 exitus, 9.6 months on average), no patient was a candidate for intestinal transplantation.

CONCLUSIONS

The survival of patients with SBS has improved in recent decades due to intestinal rehabilitation programs, advances in PN and intestinal lengthening techniques. It is possible to achieve NEC and avoiding intestinal transplantation.

摘要

引言

近几十年来,肠道康复计划、肠外营养(PN)的进展以及肠道延长技术改善了短肠综合征(SBS)患者的治疗效果。

目的

评估过去12年中诊断为SBS患者的生长情况、PN的独立性和生存率。

材料与方法

回顾性分析2007年至2016年期间的病例。将SBS定义为肠道无法通过肠内途径提供完全吸收,需要进行PN。进行多变量分析以评估由Cox回归控制的肠外营养自主性的预后因素:回盲瓣的存在(定性变量:是/否)、小肠长度和胎龄(均为定量变量)。

结果

评估了18例患者。SBS最常见的病因:坏死性小肠结肠炎(6例,33.3%)、空肠闭锁和先天性巨结肠(每种病理4例,22.2%)以及其他(4例)。诊断时平均肠道长度为51.17cm,72.2%的患者没有回盲瓣。开始时平均PN时间为115.8小时/周,目前为56.9小时/周。22.2%的患者在平均4.62年后实现了完全肠内营养(CEN)。3例患者进行了系列横断肠成形术。回盲瓣的存在是实现CEN的保护因素(p<0.018)。相比之下,肠道长度和胎龄并不显著。经过5.38年的随访(3例死亡,平均9.6个月),没有患者符合肠道移植标准。

结论

由于肠道康复计划、PN的进展和肠道延长技术,近几十年来SBS患者的生存率有所提高。有可能实现肠内营养并避免肠道移植。

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