卵胞浆内单精子注射（ICSI）后与自然流产相关的因素。
Factors associated with spontaneous abortion following intracytoplasmic sperm injection (ICSI).
作者信息
Basirat Zahra, Kashifard Mehdi, Golsorkhtabaramiri Masoumeh, Mirabi Parvaneh
机构信息
Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
出版信息
JBRA Assist Reprod. 2019 Aug 22;23(3):230-234. doi: 10.5935/1518-0557.20190028.
OBJECTIVE
The aim of this study was to describe the miscarriage rates and the factors associated with cases of spontaneous abortion observed in women offered intracytoplasmic sperm injection (ICSI).
METHODS
This cross-sectional study enrolled women who became pregnant with the aid of ICSI treated at the Babol Infertility Center (Iran) within a period of five years (2010-2015). Data were collected from patient charts and, in some cases, through phone calls. The study looked into the incidence of spontaneous abortion in women offered ICSI and the factors associated with miscarriage. The chi-square test, Fisher's exact test, and the t-test were used to analyze the data.
RESULTS
From a total of 145 pregnant women, 120 were included in our study. The prevalence of miscarriage was 20%. Galactorrhea was significantly more present in patients who had miscarriages (25% vs. 9.37%, p=0.04). There was a marked difference in the duration of infertility of miscarriage and non-miscarriage patients offered ICSI (6.6±8.3 vs. 4.9±7.3 years, p=0.05). No association was found between maternal age, BMI, cause of infertility, hormonal pattern, type of infertility, history of surgery, polycystic ovary syndrome, number of oocytes, or day of retrieval with miscarriage.
目的
本研究旨在描述接受卵胞浆内单精子注射（ICSI）的女性中流产率及与自然流产病例相关的因素。
方法
这项横断面研究纳入了在五年内（2010 - 2015年）于伊朗巴博尔不孕不育中心接受ICSI治疗并怀孕的女性。数据从患者病历中收集，部分情况通过电话获取。该研究调查了接受ICSI的女性中自然流产的发生率以及与流产相关的因素。采用卡方检验、费舍尔精确检验和t检验分析数据。
结果
在总共145名孕妇中，120名被纳入我们的研究。流产发生率为20%。流产患者中溢乳情况显著更多（25%对9.37%，p = 0.04）。接受ICSI的流产和未流产患者的不孕持续时间存在显著差异（6.6±8.3对4.9±7.3年，p = 0.05）。未发现产妇年龄、体重指数、不孕原因、激素模式、不孕类型、手术史、多囊卵巢综合征、卵母细胞数量或取卵日与流产之间存在关联。
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