Chang Yan Fang, Hu Wei Min
Department of Neurology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Apr 28;41(2):248-255. doi: 10.3881/j.issn.1000-503X.10802.
The mammalian target of rapamycin(mTOR)is a serine/threonine protein kinase that regulates protein synthesis and degradation,cytoskeletal formation,and cell longevity.Autophagy,a catabolic process necessary for the maintenance of intracellular homeostasis,is essential for cell survival,whereas mTOR is the crucial regulator of autophagy.Alzheimer's disease(AD)is the most common cause of progressive dementia in the elderly.It has been shown that disorders of mTOR and autophagy signaling pathways are closely related to AD.In the present review,we describe the regulatory roles of mTOR signaling and autophagy pathway in AD brain and introduce drugs for AD acting via modulation of autophagy and mTOR.
雷帕霉素哺乳动物靶点（mTOR）是一种丝氨酸/苏氨酸蛋白激酶，可调节蛋白质合成与降解、细胞骨架形成以及细胞寿命。自噬是维持细胞内稳态所必需的分解代谢过程，对细胞存活至关重要，而mTOR是自噬的关键调节因子。阿尔茨海默病（AD）是老年人进行性痴呆最常见的病因。已有研究表明，mTOR和自噬信号通路紊乱与AD密切相关。在本综述中，我们描述了mTOR信号和自噬通路在AD脑内的调节作用，并介绍了通过调节自噬和mTOR发挥作用的AD治疗药物。
