Barbara Ann Karmanos Cancer Institute, Population Studies and Disparities Research, Wayne State University, Detroit, Michigan, USA.
Department of Medicine, Duke Cancer Institute, Duke University, Durham, North Carolina, USA.
J Clin Invest. 2019 May 6;129(6):2187-2188. doi: 10.1172/JCI128707.
African Americans are at increased risk of cancer and associated mortalities compared with European American populations. Socioeconomic, cultural, and biological factors have been implicated in this discrepancy. In this issue of the JCI, Piyarathna et al. identify a set of genes that are upregulated in a number of tumor types in African American cancer patients as compared with European American patients. These genes were associated with enhanced oxidative phosphorylation and upregulation of transcription factors that promote mitochondrial biogenesis, resulting in greater numbers of mitochondria in tumor samples from African American subjects. Together, these results indicate that mitochondria dysfunction may underlie the increased cancer incidence and poor outcomes observed in African American patients.
与欧洲裔美国人相比，非裔美国人罹患癌症及相关死亡率的风险增加。社会经济、文化和生物学因素与这种差异有关。在本期《临床检查杂志》中，Piyarathna 等人确定了一组基因，与欧洲裔美国人患者相比，这些基因在非裔美国人癌症患者的多种肿瘤类型中上调。这些基因与增强的氧化磷酸化以及促进线粒体生物发生的转录因子的上调有关，导致来自非裔美国受试者的肿瘤样本中线粒体数量增加。总的来说，这些结果表明，线粒体功能障碍可能是非裔美国患者癌症发病率增加和预后不良的基础。
