Garcia Casallas Julio Cesar, Robayo-Amortegui H, Corredor-Rozo Z, Carrasco-Márquez A M, Escobar-Perez Javier
Facultad de Medicina, Evidence Therapeutic Group, Universidad de La Sabana, Campus Universitario, Km 7, Vía La Caro, Autopista Norte, Chía, Cundinamarca, Colombia.
Clinical Pharmacology Department, Clínica Universidad de La Sabana, Chía, Cundinamarca, Colombia.
J Med Case Rep. 2019 May 8;13(1):141. doi: 10.1186/s13256-019-2062-3.
Carbapenem-resistant Acinetobacter baumannii infections are a major public health problem worldwide, requiring the use of "old" antibiotics such as polymyxin B and E (colistin). However, there is concern regarding the emergence of isolates resistant to these antibiotics.
We report a case of a 64-year-old mestizo man hospitalized in an intensive care unit of a health institution in Colombia with identification and clinical and molecular typing of a colistin- and carbapenem-resistant A. baumannii isolate with mechanisms of resistance to colistin not previously reported, causing bacteremia.
We have identified a strain of A. baumannii with mechanisms of resistance to colistin not previously reported in a patient with bacteremia who required treatment with multiple antibiotic schemes and had an adequate response.
耐碳青霉烯类鲍曼不动杆菌感染是全球主要的公共卫生问题，需要使用“老”抗生素，如多粘菌素B和E（粘菌素）。然而，人们担心对这些抗生素耐药的菌株会出现。
我们报告了一例64岁的混血男性病例，该患者在哥伦比亚一家医疗机构的重症监护病房住院，对一株耐粘菌素和耐碳青霉烯类鲍曼不动杆菌进行了鉴定、临床和分子分型，其对粘菌素的耐药机制此前未见报道，该菌株导致了菌血症。
我们在一名菌血症患者中鉴定出了一株对粘菌素具有此前未见报道的耐药机制的鲍曼不动杆菌菌株，该患者需要多种抗生素治疗方案，且治疗反应良好。
