一种双功能分子策略，用于使用铱(III)配合物在水溶液中原位抑制和可视化神经氨酸酶。
A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(iii) complexes.
机构信息
Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong, China.
出版信息
Chem Commun (Camb). 2019 May 30;55(45):6353-6356. doi: 10.1039/c9cc02189b.
PMID:31065657
Abstract
We have designed for the first time a dual-functional luminescent probe and inhibitor of neuraminidase (NA), a key influenza target. The lead iridium(iii) complex exhibited enhanced inhibition against NA compared to the FDA-approved antiviral drug, oseltamivir, and could detect NA even in the presence of an autofluorescent background.
摘要
我们首次设计了一种双重功能的荧光探针和神经氨酸酶 (NA) 的抑制剂，NA 是流感的一个关键靶点。与已获 FDA 批准的抗病毒药物奥司他韦相比，先导铱 (III) 配合物对 NA 的抑制活性得到了增强，即使在存在自发荧光背景的情况下，也能够检测到 NA。
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