Quindlen E A, Bucher A P
J Neurosurg. 1987 May;66(5):729-33. doi: 10.3171/jns.1987.66.5.0729.
Extracts from 15 human cerebral tumors were tested by a fibrin-plate plasminogen-dependent assay for levels of tumor plasminogen activator (TPA) activity. The TPA activity was correlated with the amount of perineoplastic edema as quantified on computerized tomography (CT) brain scanning. Analysis of the results showed a correlation coefficient of 0.72 when all tumors were included. Analysis of the nine tumors with the highest TPA levels showed a correlation coefficient of 0.96. One metastatic tumor had the highest level of TPA activity, equivalent to a pure 100-micrograms/ml solution of urokinase, and the greatest amount of cerebral edema on CT. Meningiomas generally had the next highest levels of TPA activity and edema, followed by astrocytomas of varying grades, which generally had the lowest level of TPA activity. However, three astrocytomas that had low TPA activity also had significant edema surrounding the tumor, indicating that more than one mechanism may be producing peritumoral edema. There was no correlation between tumor size and the amount of perineoplastic edema. These preliminary results suggest that TPA's may be involved in the production of perineoplastic cerebral edema and that treatment of patients with currently available plasminogen activator inhibitors may be successful in reducing peritumoral edema.
采用纤维蛋白平板纤溶酶原依赖性分析法对15例人脑肿瘤提取物进行检测，以测定肿瘤纤溶酶原激活物（TPA）活性水平。TPA活性与计算机断层扫描（CT）脑扫描所量化的肿瘤周围水肿量相关。对结果进行分析，当纳入所有肿瘤时，相关系数为0.72。对TPA水平最高的9例肿瘤进行分析，相关系数为0.96。1例转移瘤的TPA活性水平最高，相当于100微克/毫升的纯尿激酶溶液，且CT显示的脑水肿量最大。脑膜瘤的TPA活性和水肿水平通常次之，随后是不同级别的星形细胞瘤，其TPA活性水平通常最低。然而，3例TPA活性较低的星形细胞瘤在肿瘤周围也有明显水肿，这表明可能有不止一种机制导致肿瘤周围水肿。肿瘤大小与肿瘤周围水肿量之间无相关性。这些初步结果表明，TPA可能参与肿瘤周围脑水肿的产生，并且用目前可用的纤溶酶原激活物抑制剂治疗患者可能成功减轻肿瘤周围水肿。
