精神分裂症和双相情感障碍中 Y 亚家族的 DNA 甲基化改变。
Altered DNA methylation of the Y subfamily in schizophrenia and bipolar disorder.
机构信息
Department of Medical Genetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single Cell Technology & Application, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China.
Center for Reproductive Medicine, The First Affiliated Hospital of University of Science & Technology of China, Hefei, Anhui, China.
出版信息
Epigenomics. 2019 May;11(6):581-586. doi: 10.2217/epi-2018-0139. Epub 2019 May 8.
To study DNA methylation patterns of Y subfamilies in schizophrenia (SCZ) and bipolar disorder (BPD). A bisulfite conversion-specific one-label extension method was employed to detect the Y subfamily methylation levels of peripheral blood DNA from 92 SCZ patients, 99 BPD patients and 92 controls. Hypermethylation of the Y A1 and A2 CpG sites in BPD patients and hypomethylation of A3 CpG site in both of BPD and SCZ patients, and opposite age-dependent methylation alterations between SCZ and controls. The differentially altered DNA methylation patterns of the Y families between BPD and SCZ suggest the role of DNA methylation in the pathogenesis of these major psychiatric disorders.
研究精神分裂症（SCZ）和双相情感障碍（BPD）中 Y 亚家族的 DNA 甲基化模式。采用亚硫酸氢盐转化特异性单标记延伸方法，检测 92 例 SCZ 患者、99 例 BPD 患者和 92 名对照者外周血 DNA 的 Y 亚家族甲基化水平。BPD 患者的 Y A1 和 A2 CpG 位点出现超甲基化，BPD 和 SCZ 患者的 A3 CpG 位点出现低甲基化，以及 SCZ 和对照组之间存在相反的年龄依赖性甲基化改变。BPD 和 SCZ 之间 Y 家族的 DNA 甲基化模式差异改变表明 DNA 甲基化在这些主要精神疾病发病机制中的作用。
Zotero 插件