Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4, Switzerland.
Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4, Switzerland; Swiss National Centre for Competence in Research (NCCR) in Chemical Biology, University of Geneva, Sciences II, Room 3-308, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland.
Cell Metab. 2019 May 7;29(5):1019-1021. doi: 10.1016/j.cmet.2019.04.010.
Recently in Cell, Kato et al. (2019) and Yang et al. (2019) report that reversible oxidation of multiple methionines in a region of Pbp1, the yeast paralog of ataxin-2 protein, couples metabolic redox status to phase separation of Pbp1 into liquid-like condensates. In turn, Pbp1 condensates inhibit target of rapamycin complex 1 (TORC1) signaling and thereby induce autophagy and restore metabolic homeostasis.
最近，Kato 等人（2019 年）和 Yang 等人（2019 年）在《细胞》杂志上报道称，酵母 ataxin-2 蛋白的旁系同源物 Pbp1 中的一个区域中多个蛋氨酸的可逆氧化作用将代谢氧化还原状态与 Pbp1 液-液相分离偶联起来。反过来，Pbp1 凝聚物抑制雷帕霉素靶蛋白复合物 1（TORC1）信号，从而诱导自噬并恢复代谢稳态。
