Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Medicine II, Medical Center, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
BMC Infect Dis. 2019 May 8;19(1):395. doi: 10.1186/s12879-019-4040-1.
Leptospirosis or Weil's disease is caused by pathogenic spirochete bacteria called Leptospira. It is considered the most common zoonosis in the world and is usually transmitted by urine of rodents and dogs with an incubation time of 7-14 days. The clinical spectrum ranges from a subclinical infection to a fulminant septic course.
Here, we report the case of a German patient with acute pancreatitis associated with Leptospira interrogans causing fulminant septic shock. The patient was successfully treated with intravenous antibiotics and left the hospital fully recovered after 18 days.
To our knowledge, this is the first case of leptospirosis with acute pancreatitis as the leading clinical manifestation in Central Europe. Serologic and molecular genetic tests for leptospirosis should be considered, if no other causes for pancreatitis can be identified.
钩端螺旋体病或韦尔氏病是由致病性螺旋体细菌引起的。它被认为是世界上最常见的动物源性传染病，通常通过鼠类和狗的尿液传播，潜伏期为 7-14 天。临床表现范围从亚临床感染到暴发性败血性病程。
在这里，我们报告了一例德国患者，其急性胰腺炎与钩端螺旋体 interrogans 有关，导致暴发性感染性休克。该患者经静脉内抗生素治疗后成功治愈，18 天后完全康复出院。
据我们所知，这是首例在中欧地区以急性胰腺炎为主要临床表现的钩端螺旋体病病例。如果不能确定胰腺炎的其他病因，应考虑进行钩端螺旋体病的血清学和分子遗传学检查。
