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运用定量蛋白质组学对肝移植前后的人血清进行比较蛋白质组学分析。

Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics.

作者信息

Zhang Ruohan, Ou Minglin, Zhang Yue, Yan Qiang, Chen Huaizhou, Lai Liusheng, Li Ying, Xu Feilong, Tang Donge, Sun Xuyong, Dong Jianhui, Dai Yong, Sui Weiguo

机构信息

Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department of Guilin 924st Hospital, Guilin, Guangxi 541002, P.R. China.

Clinical Medical Research Center, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, P.R. China.

出版信息

Oncotarget. 2019 Apr 2;10(26):2508-2514. doi: 10.18632/oncotarget.26761.

DOI:10.18632/oncotarget.26761
PMID:31069013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6493459/
Abstract

Liver cancer is the second leading cause of cancer mortality worldwide. Safer and more effective diagnostic methods for liver cancer are desirable, and biomarkers represent a potentially alternative method for diagnosis. The present study was designed to identify liver cancer biomarkers. We quantified the changes in serum protein levels between liver transplantation and healthy (control) females using isobaric tags for relative and absolute quantitation (iTRAQ) as well as proteomic analysis. A total of 1399 proteins were identified; of these, three proteins showed significantly different concentrations between the before transplantation group and the control group. These proteins may thus be relevant to liver cancer and constitute potential liver cancer biomarkers.

摘要

肝癌是全球癌症死亡的第二大主要原因。人们期望有更安全、更有效的肝癌诊断方法，而生物标志物代表了一种潜在的替代诊断方法。本研究旨在识别肝癌生物标志物。我们使用相对和绝对定量的等压标签（iTRAQ）以及蛋白质组学分析，对肝移植女性与健康（对照）女性之间血清蛋白水平的变化进行了定量。总共鉴定出1399种蛋白质；其中，三种蛋白质在移植前组和对照组之间显示出显著不同的浓度。因此，这些蛋白质可能与肝癌相关，并构成潜在的肝癌生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f018/6493459/c5e1563965ac/oncotarget-10-2508-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f018/6493459/94a3ed857359/oncotarget-10-2508-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f018/6493459/0641e2446394/oncotarget-10-2508-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f018/6493459/c5e1563965ac/oncotarget-10-2508-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f018/6493459/94a3ed857359/oncotarget-10-2508-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f018/6493459/0641e2446394/oncotarget-10-2508-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f018/6493459/c5e1563965ac/oncotarget-10-2508-g003.jpg

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本文引用的文献

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The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer.癌症相关成纤维细胞和纤维化在肝癌中的作用
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