Miller Joseph P, Borde Brandon H, Bordeleau Francois, Zanotelli Matthew R, LaValley Danielle J, Parker Dylan J, Bonassar Lawrence J, Pannullo Susan C, Reinhart-King Cynthia A
Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA.
APL Bioeng. 2018 Apr 3;2(3):031901. doi: 10.1063/1.5018327. eCollection 2018 Sep.
Cells receive mechanical cues from their extracellular matrix (ECM), which direct migration, differentiation, apoptosis, and in some cases, the transition to a cancerous phenotype. As a result, there has been significant research to develop methods to tune the mechanical properties of the ECM and understand cell-ECM dynamics more deeply. Here, we show that ionizing radiation can reduce the stiffness of an tumor and an collagen matrix. When non-irradiated cancer cells were seeded in the irradiated matrix, adhesion, spreading, and migration were reduced. These data have ramifications for both and systems. , these data suggest that irradiation may be a method that could be used to create matrices with tailored mechanical properties. , these suggest that therapeutic doses of radiation may alter tissue mechanics directly.
细胞从其细胞外基质（ECM）接收机械信号，这些信号指导细胞迁移、分化、凋亡，在某些情况下还指导向癌性表型的转变。因此，人们进行了大量研究来开发调节ECM机械性能的方法，并更深入地了解细胞与ECM的动态关系。在这里，我们表明电离辐射可以降低肿瘤和胶原蛋白基质的硬度。当未受辐射的癌细胞接种到受辐射的基质中时，细胞黏附、铺展和迁移都会减少。这些数据对肿瘤学和组织工程系统都有影响。一方面，这些数据表明辐射可能是一种可用于创建具有定制机械性能基质的方法。另一方面，这些数据表明治疗剂量的辐射可能直接改变组织力学。
