环糊精作为手性选择剂：综述

Cyclofructans as Chiral Selectors: An Overview.

作者信息

Hellinghausen Garrett, Armstrong Daniel W

机构信息

Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, USA.

出版信息

Methods Mol Biol. 2019;1985:183-200. doi: 10.1007/978-1-4939-9438-0_11.

DOI:10.1007/978-1-4939-9438-0_11

PMID:31069736

Abstract

Cyclofructans are cyclic oligosaccharides made of β-2,1-linked fructofuranose units. They have been utilized as chiral selectors, usually after derivatization, with high-performance liquid chromatography (HPLC), gas chromatography (GC), capillary electrophoresis (CE), and supercritical fluid chromatography (SFC). The focus herein will be directed to their development and applications as chiral selectors in various chiral separation techniques. Discussion of their use in hydrophilic liquid interaction chromatography (HILIC) will be limited. Their use in liquid chromatography, especially their improvements with the use of superficially porous particles (SPPs) will be emphasized. Method parameters and future directions are also discussed.

摘要

环糊精是由β-2,1-连接的呋喃果糖单元组成的环状寡糖。它们通常在衍生化后用作手性选择剂，应用于高效液相色谱（HPLC）、气相色谱（GC）、毛细管电泳（CE）和超临界流体色谱（SFC）。本文将重点关注它们作为手性选择剂在各种手性分离技术中的发展和应用。对其在亲水液相相互作用色谱（HILIC）中的应用讨论将较为有限。将着重强调它们在液相色谱中的应用，特别是使用表面多孔颗粒（SPP）后的改进。还讨论了方法参数和未来方向。