Tong Sheng-Qiang
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, People's Republic of China.
Methods Mol Biol. 2019;1985:321-337. doi: 10.1007/978-1-4939-9438-0_17.
Chiral separations by countercurrent chromatography are mainly divided into two types: homogeneous chiral selector addition and interfacial chiral ligand exchange. In this chapter, we describe two methods for the enantioseparation of phenylsuccinic acid and α-hydroxy acids by high-speed countercurrent chromatography using hydroxypropyl-β-cyclodextrin and N-n-dodecyl-L-proline as chiral selectors for both above mentioned modes.
均相手性选择剂添加和界面手性配体交换。在本章中，我们描述了两种使用羟丙基-β-环糊精和N-正十二烷基-L-脯氨酸作为上述两种模式的手性选择剂，通过高速逆流色谱法对苯基琥珀酸和α-羟基酸进行对映体拆分的方法。
