From the Aix-Marseille University, Center for CardioVascular and Nutrition Research, INSERM 1263, INRA 1260, France (A.S.L., M.G.B., R.B., N.B., M.B.-C., F.D.-G.).
Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, France (N.B., F.D.-G.).
Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1026-1033. doi: 10.1161/ATVBAHA.119.312653.
CD146 (cluster of differentiation 146) is an adhesion molecule that is expressed by different cells constituting vessels, particularly endothelial cells. The last 30 years of research in this field have shown that CD146 plays a key role in the control of several vessel functions. Three forms of CD146 have been described, including 2 transmembrane isoforms and a soluble protein that is detectable in the plasma. These CD146 forms mediate pleiotropic functions through homophilic and heterophilic interactions with proteins present on surrounding partners. Several studies used neutralizing antibodies, siRNA, or genetically modified mice to demonstrate the involvement of CD146 in the regulation of angiogenesis, vascular permeability, and leukocyte transmigration. In this review, we will focus on the current knowledge of the roles of CD146 in vascular homeostasis and diseases associated with endothelial dysfunction.
CD146（分化群 146）是一种黏附分子，由构成血管的不同细胞表达，特别是内皮细胞。该领域过去 30 年的研究表明，CD146 在控制几种血管功能方面发挥着关键作用。已经描述了 3 种 CD146 形式，包括 2 种跨膜同工型和一种可在血浆中检测到的可溶性蛋白。这些 CD146 形式通过与周围配体上存在的蛋白的同亲性和异亲性相互作用介导多效性功能。一些研究使用中和抗体、siRNA 或基因修饰的小鼠来证明 CD146 参与了血管生成、血管通透性和白细胞迁移的调节。在这篇综述中，我们将重点介绍 CD146 在血管稳态和与内皮功能障碍相关疾病中的作用的最新知识。
