1 Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
2 Department of Radiology, Peking University Cancer Hospital & Institute, Beijing, China.
Cancer Biother Radiopharm. 2019 May;34(4):224-230. doi: 10.1089/cbr.2018.2696.
This study is aimed to evaluate the iodine concentration in the lipid-poor portion of the renal mass as a potential tool for the differentiation between angiomyolipoma (AML) and renal cell carcinoma (RCC). There were eight cases of AML and eight cases of RCC. All patients received corticomedullary, nephrographic and excretory phase enhanced scanning. The regions of interest (ROI) were manually placed in the lipid-poor portion of the renal mass and in the abdominal aorta. Average iodine concentrations were obtained for the ROIs and abdominal aorta. Data were compared using repeated measures analysis with the Bonferroni correction for multiple comparisons. At the unenhanced phase, the iodine concentration in the lipid-poor portion of the renal mass of RCC was not significantly different from that of AML ( = 0.298). At the three enhanced phases, the iodine concentrations in the renal mass of RCC were substantially elevated compared with those of AML. In addition, the CT values of the renal mass of RCC were significantly higher than those of AML at all the enhanced phases. Of note, there was a significant correlation between iodine concentrations and CT values ( = 0.919; < 0.001) in the lipid-poor portion of the renal mass of RCC. Between RCC and AML there was significant difference in iodine concentrations in the lipid-poor portion of the renal masses. Iodine concentration holds promise as a diagnostic alternative to macroscopic fat for differentiation of AML from RCC.
本研究旨在评估乏脂部分肾实质内的碘浓度作为鉴别血管平滑肌脂肪瘤（AML）和肾细胞癌（RCC）的一种潜在方法。共有 8 例 AML 和 8 例 RCC 患者。所有患者均接受皮质髓质、肾图和排泄期增强扫描。手动将感兴趣区（ROI）放置在肾实质乏脂部分和腹主动脉内。获得 ROI 和腹主动脉的平均碘浓度。使用重复测量分析和 Bonferroni 校正进行多重比较来比较数据。 在未增强期，RCC 乏脂部分肾实质的碘浓度与 AML 无显著差异（ = 0.298）。在三个增强期，RCC 肾实质的碘浓度明显高于 AML。此外，在所有增强期，RCC 肾实质的 CT 值均显著高于 AML。值得注意的是，RCC 乏脂部分肾实质的碘浓度与 CT 值之间存在显著相关性（ = 0.919； < 0.001）。 在 RCC 和 AML 之间，肾实质乏脂部分的碘浓度存在显著差异。碘浓度有望成为一种替代宏观脂肪的诊断方法，用于鉴别 AML 和 RCC。
