Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.
Department of Dermatology, University of California Davis School of Medicine, Sacramento, California.
Dermatol Ther. 2019 Jul;32(4):e12954. doi: 10.1111/dth.12954. Epub 2019 May 20.
A 40-year-old man with chronic history of refractory palmoplantar psoriasis presented with new onset of well-demarcated oval erythematous asteatotic plaques on bilateral shins after starting guselkumab therapy. Histopathology revealed chronic spongiotic dermatitis consistent with a diagnosis of nummular dermatitis. This case highlights a previously unreported adverse event to guselkumab therapy.
一位 40 岁男性，慢性难治性掌跖银屑病病史，在开始使用古塞库单抗治疗后，双侧小腿出现新的边界清楚的卵圆形红斑性非湿疹性斑块。组织病理学显示慢性海绵状皮炎，符合钱币状皮炎的诊断。本病例突出了古塞库单抗治疗的一种先前未报道的不良反应。
