丙烯醛使血浆α1-蛋白酶抑制剂失活的可能机制。
Plausible mechanism of inactivation of plasma alpha 1-proteinase inhibitor by acrolein.
作者信息
Gan J C, Ansari G A
出版信息
Res Commun Chem Pathol Pharmacol. 1987 Mar;55(3):419-22.
PMID:3107096
Abstract
Evidence is presented to show that inactivation of alpha 1-proteinase inhibitor caused by acrolein depends upon the modification of lysine and histidine residues. Approximately 90% activity was lost when twenty three lysine and eight histidine residues were modified.
摘要
有证据表明，丙烯醛导致的α1-蛋白酶抑制剂失活取决于赖氨酸和组氨酸残基的修饰。当二十三个赖氨酸残基和八个组氨酸残基被修饰时，约90%的活性丧失。
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