Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Ministry of Education, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, People's Republic of China.
Nanotechnology. 2019 Aug 30;30(35):355604. doi: 10.1088/1361-6528/ab209d. Epub 2019 May 9.
The synthesis of drug delivery systems based on surface-modified mesoporous silica hollow structures remains a huge challenge. In this paper, we have obtained hollow mesoporous silica nanoparticles (MSNs) by surfactant directed sol-gel assisted hydrothermal treatment. The MSNs have the inorganic-organic hybrid frameworks with uniform diameter distribution (260 nm), and their specific surface area, mesoporous size and pore volume are 540 m g, 3.7 nm, 0.58 cm g, respectively. It was proved that the preparation of hollow ethane-bridged nanospheres with two silicon source was due to the high crosslinking of the silicone interface and hydrothermal treatment, providing a new approach for the study of drug-loaded and controlled release behavior. Based on the synthesis of MSNs, MSNs were modified by methacryloxy propyl trimethoxyl silane (MPS) on the surface of MSNs. Then N-isopropylacryamide (NIPAM) and acrylic acid (AA) were grafted onto the surface of modified MSNs. The hollow ethane-bridged PNA-MSNs (poly (NIPAM-co-acrylic acid)-MSNs) with two silicon source were prepared successfully. Due to their distinctive hollow structure, PNA-MSNs demonstrated high drug encapsulation efficiency (70.4% ± 2.9%). The experiment results proved that the modified hollow nanoparticles not only had good biocompatibility and stability, but also possessed pH-/thermal-dual responsiveness in drug release.
基于表面修饰的介孔硅中空结构的药物传递系统的合成仍然是一个巨大的挑战。在本文中，我们通过表面活性剂导向的溶胶-凝胶辅助水热处理得到了中空介孔硅纳米粒子（MSNs）。MSNs 具有均匀粒径分布（260nm）的无机-有机杂化骨架，其比表面积、介孔尺寸和孔体积分别为 540m²/g、3.7nm 和 0.58cm³/g。证明了使用两种硅源制备具有中空乙撑桥的纳米球是由于硅界面的高交联和水热处理，为载药和控制释放行为的研究提供了新的途径。基于 MSNs 的合成，通过在 MSNs 表面修饰甲氧基丙基三甲氧基硅烷（MPS），然后在改性 MSNs 表面接枝 N-异丙基丙烯酰胺（NIPAM）和丙烯酸（AA），成功制备了具有中空乙撑桥的双硅源 PNA-MSNs（聚（NIPAM-co-丙烯酸）-MSNs）。由于其独特的中空结构，PNA-MSNs 表现出了较高的药物包封效率（70.4%±2.9%）。实验结果证明，修饰后的中空纳米粒子不仅具有良好的生物相容性和稳定性，而且在药物释放中具有 pH-/热双重响应性。
