School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Int J Mol Sci. 2019 May 8;20(9):2276. doi: 10.3390/ijms20092276.
Group 2 innate lymphoid cells (ILC2) have emerged as a major component of type 2 inflammation in mice and humans. ILC2 secrete large amounts of interleukins 5 and 13, which are largely responsible for host protective immunity against helminth parasites because these cytokines induce profound changes in host physiology that include: goblet cell metaplasia, mucus accumulation, smooth muscle hypercontractility, eosinophil and mast cell recruitment, and alternative macrophage activation (M2). This review covers the initial recognition of ILC2 as a distinct cell lineage, the key studies that established their biological importance, particularly in helminth infection, and the new directions that are likely to be the focus of emerging work that further explores this unique cell population in the context of health and disease.
2 型固有淋巴细胞 (ILC2) 已成为小鼠和人类 2 型炎症的主要组成部分。ILC2 大量分泌白细胞介素 5 和 13，这在很大程度上负责宿主对寄生虫的保护性免疫，因为这些细胞因子诱导宿主生理学的深刻变化，包括：杯状细胞化生、粘液积聚、平滑肌过度收缩、嗜酸性粒细胞和肥大细胞募集以及替代型巨噬细胞激活 (M2)。这篇综述涵盖了最初将 ILC2 识别为一个独特的细胞谱系、确立其生物学重要性的关键研究，特别是在寄生虫感染方面，以及可能成为新兴工作的重点的新方向，这些工作将进一步在健康和疾病背景下探索这一独特的细胞群体。
