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具有 logistic 靶细胞生长的年龄结构 HIV 感染模型的 Hopf 分支。

Hopf bifurcation of an age-structured HIV infection model with logistic target-cell growth.

机构信息

a College of Electrical and Information Engineering , Lanzhou University of Technology , Lanzhou , People's Republic of China.

c Department of Science, College of Technology and Engineering , Lanzhou University of Technology , Lanzhou , People's Republic of China.

出版信息

J Biol Dyn. 2019 Dec;13(1):362-384. doi: 10.1080/17513758.2019.1602171.

Abstract

In this paper, we investigate an age-structured HIV infection model with logistic growth for target cell. We rewrite the model as an abstract non-densely defined Cauchy problem and obtain the condition which guarantees the existence of the unique positive steady state. By linearizing the model at steady state and analysing the associated characteristic transcendental equations, we study the local asymptotic stability of the steady state. Furthermore, by using Hopf bifurcation theorem in Liu et al., we show that Hopf bifurcation occurs at the positive steady state when bifurcating parameter crosses some critical values. Finally, we perform some numerical simulations to illustrate our results.

摘要

本文研究了具有 logistic 增长的目标细胞的年龄结构 HIV 感染模型。我们将模型重写为抽象的非稠密定义的 Cauchy 问题,并得到了保证唯一正平衡点存在的条件。通过在平衡点处线性化模型并分析相关的特征超越方程,我们研究了平衡点的局部渐近稳定性。此外,利用 Liu 等人的 Hopf 分岔定理,我们表明当分岔参数穿过某些临界值时,正平衡点处发生 Hopf 分岔。最后,我们进行了一些数值模拟来验证我们的结果。

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