Cancer Discov. 2019 Jul;9(7):822. doi: 10.1158/2159-8290.CD-ND2019-004. Epub 2019 May 9.
Oncologists are testing fecal transplants and other microbiome-based products in combination with checkpoint inhibitors in an effort to increase and enhance responses. However, questions remain about how the microbes affect host immunity and which preparations of bacteria are optimal.
肿瘤学家正在尝试将粪便移植和其他基于微生物组的产品与检查点抑制剂联合使用,以提高和增强反应。然而,人们仍然不清楚微生物如何影响宿主免疫,以及哪种细菌制剂是最佳的。