Gerris J, Desmedt E, Delbeke L, Buytaert P, Gerris J, Van Gaal L
Acta Eur Fertil. 1986 Jul-Aug;17(4):251-8.
Sixty-three patients treated with exogenous gonadotropins for a total of 232 non-IVF cycles were monitored by serum E2 and/or total urinary estrogen excretion. The endocrine profile of follicular phase during HMG-HCG stimulation was evaluated with regard to an effect on the pregnancy rate. Six different follicular phase patterns were observed: A-profiles (daily exponential increase of sE2 or total urinary estrogen values followed by a sustained exponential increase on the day after HCG injection) seem to be necessary to obtain pregnancy, being followed by conception in 21.5% of all cases. Other profiles have lower conception rate (10%); no conception occurred when non exponential E2 rise was observed. The different responses are not related to total dosage of HLG administered. Patients who were treated for hypogonadotropic hypogonadism had a high pregnancy rate (80%) even in absence of post-HCG estrogen rise (G-endocrine profiles. Women aged 35 years must have significantly higher doses of gonadotropins to obtain A-profiles. Monitoring by E2 seems to be more adequate than the TUE only (conceptual pregnancy rate/cycle of 15.25%, versus 10.34%). In conception cycle, midluteal E2/P ratio never exceeds 50.
63例接受外源性促性腺激素治疗、共进行232个非体外受精周期的患者，通过血清雌二醇（E2）和/或尿总雌激素排泄量进行监测。就对妊娠率的影响而言，对人绝经期促性腺激素-人绒毛膜促性腺激素（HMG-HCG）刺激期间的卵泡期内分泌情况进行了评估。观察到六种不同的卵泡期模式：A型模式（血清E2或尿总雌激素值每日呈指数增加，随后在注射HCG后的次日持续呈指数增加）似乎是妊娠所必需的，在所有病例中有21.5%随后受孕。其他模式的受孕率较低（10%）；当观察到E2呈非指数性升高时未发生受孕。不同反应与所给予的人绝经期促性腺激素（HLG）总剂量无关。接受低促性腺激素性性腺功能减退治疗的患者，即使在注射HCG后雌激素未升高（G型内分泌模式）的情况下也有较高的妊娠率（80%）。35岁及以上的女性必须使用明显更高剂量的促性腺激素才能获得A型模式。通过E2进行监测似乎比仅通过尿总雌激素（TUE）监测更合适（受孕周期的概念性妊娠率为15.25%，而TUE为10.34%）。在受孕周期中，黄体中期E2/孕酮（P）比值从未超过50。
