Saleem A, Irani D R, Bart J B, Alfrey C P
Acta Haematol. 1987;77(1):34-7. doi: 10.1159/000205946.
Disorders of iron metabolism affect the expression of hemoglobin H in hemoglobin H disease. Two cases of iron deficiency with reduced synthesis of hemoglobin H are described in the literature. We report two more cases, one with anemia of chronic disease and another with alcoholic sideroblastic anemia where the hemoglobin H was not detected at presentation and appeared after treatment of the underlying disorder. The pathogenesis of suppression of hemoglobin H is discussed.
铁代谢紊乱会影响血红蛋白H病中血红蛋白H的表达。文献中描述了两例缺铁伴血红蛋白H合成减少的病例。我们报告另外两例，一例为慢性病贫血，另一例为酒精性铁粒幼细胞贫血，这两例在就诊时均未检测到血红蛋白H，而在基础疾病治疗后出现了血红蛋白H。本文讨论了血红蛋白H受抑制的发病机制。
