骨与缝的生物力学——猪模型研究结果
Mechanobiology of bone and suture - Results from a pig model.
机构信息
Department of Orthodontics, University of Washington, Seattle, Washington.
Department of Oral Health Sciences, University of Washington, Seattle, Washington.
出版信息
Orthod Craniofac Res. 2019 May;22 Suppl 1(Suppl 1):82-89. doi: 10.1111/ocr.12276.
OBJECTIVE
To compare the morphology and mechanical function of sutures in normal pigs and minipigs to those of Yucatan minipigs, a natural model for midfacial hypoplasia.
SETTING AND SAMPLE POPULATION
Research took place at the Department of Orthodontics at the University of Washington and used varying sample sizes of normal-snouted pigs and Yucatan minipigs.
MATERIAL AND METHODS
Skulls and heads were examined for morphology of the nasofrontal suture using computed tomography and histology. Strain gauge recordings were made of sutural strain during mastication and during cyclic tensile loading of the nasofrontal suture.
RESULTS
Sutures in Yucatans had narrower gaps than same-age normal pigs. The nasofrontal suture was simpler in construction and had more active osteoblasts on the bone fronts in Yucatans. The sutural ligament was less well organized, and based on a small sample, masticatory strain appeared to be lower than in normal minipigs. However, sutures were not fused and showed similar strains in response to the cyclic loading procedure.
CONCLUSION
Midfacial hypoplasia in Yucatan pigs has the likely proximate cause of hyperossification. Yet prior to fusion, the sutures appear to be amenable to treatment that would promote their growth rate.
目的
比较正常猪和尤卡坦小型猪（一种面中部发育不全的天然模型）的缝线形态和力学功能。
地点和样本人群
研究在华盛顿大学正畸系进行，使用了不同大小的正常猪和尤卡坦小型猪样本。
材料和方法
使用计算机断层扫描和组织学检查对头骨和头部的鼻额缝形态进行检查。在咀嚼和鼻额缝周期性拉伸加载过程中，对缝线应变进行应变计记录。
结果
尤卡坦小型猪的缝线间隙比同龄正常猪窄。鼻额缝结构更简单，在尤卡坦小型猪的骨前缘有更多活跃的成骨细胞。缝线韧带组织不太规整，根据一个小样本，咀嚼时的应变似乎低于正常小型猪。然而，缝线没有融合，在周期性加载过程中表现出相似的应变。
结论
尤卡坦小型猪的面中部发育不全可能是由于过度骨化所致。然而，在融合之前，缝线似乎可以通过治疗来促进其生长速度。
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