Chengdu Institute of Biology , Chinese Academy of Sciences , Chengdu 610041 , China.
University of Chinese Academy of Sciences , Beijing 100049 , China.
Org Lett. 2019 Jun 7;21(11):3913-3917. doi: 10.1021/acs.orglett.9b00908. Epub 2019 May 10.
A new Cu-catalyzed enantioselective three-component (i.e., styrenes, Bpin, and propargylic phosphates) allenylation via an S2' substitution of propargylic electrophiles with vinylarene-derived chiral nucleophiles is presented. This method provides an efficient and enantioselective approach to access a range of optically pure di-(1,1-), tri-, and tetra-substituted allenes with α-central chirality and axial chirality in excellent chemo-, regio-, diastereo-, and enantioselectivities.
本文报道了一种新型的 Cu 催化的对映选择性三组分（即苯乙烯、Bpin 和炔丙基膦酸酯）烯丙基化反应，通过亲核试剂对炔丙基亲电试剂的 S2'取代反应实现。该方法为构建一系列具有α-中心手性和轴向手性的光学纯的二-（1,1-）、三-和四取代的烯丙基化合物提供了一种高效、对映选择性的方法，具有优异的化学选择性、区域选择性、非对映选择性和对映选择性。
