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SGLT2 inhibitors: reviving the sodium-hydrogen exchanger cardioprotection hypothesis?

作者信息

Arjun Sapna, Bell Robert M

机构信息

Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, UK.

出版信息

Cardiovasc Res. 2019 Aug 1;115(10):1454-1456. doi: 10.1093/cvr/cvz105.

DOI:10.1093/cvr/cvz105
PMID:31074777
Abstract
摘要

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Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts.依帕列净延迟缺血性挛缩的发作与 NHE1 抑制有关,并依赖于分离的小鼠心脏中的胰岛素。
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Cardiovasc Res. 2024 Mar 14;120(3):301-317. doi: 10.1093/cvr/cvae004.
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A state-of-the-art review of the current role of cardioprotective techniques in cardiac transplantation.一篇关于心脏移植中心肌保护技术当前作用的最新综述。
Interact Cardiovasc Thorac Surg. 2021 May 10;32(5):683-694. doi: 10.1093/icvts/ivaa333.
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Mitochondrial Ca, redox environment and ROS emission in heart failure: Two sides of the same coin?
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A Call for a New Paradigm for Diabetes Care in the Era of Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i).钠-葡萄糖协同转运蛋白2抑制剂(SGLT2i)时代糖尿病护理新范式的呼吁
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Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition.恩格列净可降低高糖诱导的氧化应激和 miR-21 依赖的 TRAF3IP2 诱导及 REck 抑制,从而抑制人肾近端肾小管上皮细胞迁移和上皮间质转化。
Cell Signal. 2020 Apr;68:109506. doi: 10.1016/j.cellsig.2019.109506. Epub 2019 Dec 17.