基因多态性与特发性膜性肾病的风险。

Gene polymorphism and risk of idiopathic membranous nephropathy.

机构信息

Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Research Institute of Nephrology, Zhengzhou University, Zhengzhou, China; Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou, China; Core Unit of National Clinical Medical Research Center of Kidney Disease, Zhengzhou, China.

出版信息

Life Sci. 2019 Jul 15;229:124-131. doi: 10.1016/j.lfs.2019.05.010. Epub 2019 May 7.

DOI:10.1016/j.lfs.2019.05.010

PMID:31075233

Abstract

Membranous nephropathy (MN) is the most common primary glomerular disease (PGD) in the world. Currently, MN still lacks specific diagnostic markers and effective treatment strategy. It is speculated that the occurrence of MN is mainly related to environmental and genetic factors. The pathological manifestations of MN patients are diverse, significant differences in response to treatment options, and more reports on young MN patients suggest the importance of genes in the pathogenesis and diagnosis of MN. We will propose a novel perspective on the important role of genes in the pathogenesis of MN baced on the latest research.

摘要

膜性肾病（MN）是世界上最常见的原发性肾小球疾病（PGD）。目前，MN 仍然缺乏特异性的诊断标志物和有效的治疗策略。据推测，MN 的发生主要与环境和遗传因素有关。MN 患者的病理表现多样，对治疗方案的反应存在显著差异，且越来越多的关于年轻 MN 患者的报告提示基因在 MN 的发病机制和诊断中具有重要作用。我们将根据最新的研究提出一个关于基因在 MN 发病机制中重要作用的新观点。