Chan W K, Fong C Y, Tiong H H, Tan C H
Biochem Biophys Res Commun. 1987 Apr 14;144(1):166-71. doi: 10.1016/s0006-291x(87)80490-4.
Addition of 17 beta-N,N,-diethylcarbamoyl-4-methyl-4-aza-5 alpha-androstane-3-one, a potent 5 alpha-reductase inhibitor, to granulosa cell cultures inhibited the FSH-stimulated progesterone synthesis during both the initial 48 h induction period and the subsequent 6h test period in a dose-dependent fashion. Besides being a more potent inhibitor of FSH-stimulated progesterone synthesis than testosterone, 4-MA also synergized with the androgen to inhibit progesterone synthesis. These results indicate that 4-MA has a direct inhibitory action on 3 beta-HSD.
向颗粒细胞培养物中添加强效5α-还原酶抑制剂17β-N，N-二乙基氨基甲酰基-4-甲基-4-氮杂-5α-雄甾烷-3-酮，在最初的48小时诱导期和随后的6小时测试期内，均以剂量依赖性方式抑制促卵泡激素（FSH）刺激的孕酮合成。4-MA不仅是比睾酮更强效的FSH刺激孕酮合成抑制剂，还与雄激素协同抑制孕酮合成。这些结果表明，4-MA对3β-羟基类固醇脱氢酶（3β-HSD）具有直接抑制作用。
