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Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity.

作者信息

Cooney D A, Ahluwalia G, Mitsuya H, Fridland A, Johnson M, Hao Z, Dalal M, Balzarini J, Broder S, Johns D G

出版信息

Biochem Pharmacol. 1987 Jun 1;36(11):1765-8. doi: 10.1016/0006-2952(87)90235-8.

DOI:10.1016/0006-2952(87)90235-8
PMID:3107569
Abstract
摘要

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1
Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity.
Biochem Pharmacol. 1987 Jun 1;36(11):1765-8. doi: 10.1016/0006-2952(87)90235-8.
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Enzymatic properties of the unnatural beta-L-enantiomers of 2',3'-dideoxyadenosine and 2',3'-didehydro-2',3'-dideoxyadenosine.
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Investigations on the anti-HIV activity of 2',3'-dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HIV activity of 2,6-diaminopurine 2',3'-dideoxyriboside.
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The role of adenosine and 2'-deoxyadenosine in mammalian cells.腺苷和2'-脱氧腺苷在哺乳动物细胞中的作用。
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AIDS Res Hum Retroviruses. 1989 Oct;5(5):541-50. doi: 10.1089/aid.1989.5.541.

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