Department of Rehabilitation Medicine, Burn Center, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
School of Business Administration, Hallym University, Chuncheon, Republic of Korea.
Burns. 2019 Sep;45(6):1430-1437. doi: 10.1016/j.burns.2019.04.019. Epub 2019 May 7.
This cross-sectional study aimed to investigate whether adipose tissue loss and reduced vitamin D levels following severe burn injury are associated with pathologic scar formation and biomechanical scar properties.
A total of 492 male subjects with hypertrophic burn scars were enrolled from January 2014 to July 2018 and analyzed. Body fat content was measured using dual-energy X-ray absorptiometry. Values of melanin, erythema, and trans-epidermal water loss (TEWL) and the distensibility and elasticity of hypertrophic scars were examined using pigment- and TEWL-measuring devices and a suction skin elasticity meter.
Burn patients with higher fat percentage tended to have higher 25(OH) vitamin D levels (P < 0.001). As body fat percentage increased, hypertrophic scars showed higher mean value of Uf (distensibility, P < 0.001) and lower mean value of Uv/Ue (viscoelasticity or interstitial fluid shifting, P < 0.001). Burn patients with higher 25(OH) vitamin D levels tended to have higher mean values of Uf (P < 0.001) and Ua/Uf (gross elasticity, P = 0.013) and lower mean value of Uv/Ue (P = 0.008).
Adipose tissue loss and decreased 25(OH) vitamin D levels following burn injury were related to scar rigidity and slow interstitial fluid shifting in hypertrophic scars.
本横断面研究旨在探讨严重烧伤后脂肪组织丢失和维生素 D 水平降低是否与病理性瘢痕形成和生物力学瘢痕特性有关。
2014 年 1 月至 2018 年 7 月，共纳入 492 例男性肥厚性烧伤瘢痕患者进行分析。采用双能 X 射线吸收法测量体脂肪含量。使用色素和 TEWL 测量仪以及皮肤弹性计测量黑素、红斑和经表皮水分丢失 (TEWL)值以及肥厚性瘢痕的伸展性和弹性。
脂肪百分比较高的烧伤患者 25(OH) 维生素 D 水平较高（P < 0.001）。随着体脂肪百分比的增加，肥厚性瘢痕的 Uf（伸展性，P < 0.001）平均值升高，Uv/Ue（粘弹性或间质液转移，P < 0.001）平均值降低。25(OH) 维生素 D 水平较高的烧伤患者 Uf（P < 0.001）和 Ua/Uf（总体弹性，P = 0.013）的平均值较高，Uv/Ue（P = 0.008）的平均值较低。
烧伤后脂肪组织丢失和 25(OH) 维生素 D 水平降低与肥厚性瘢痕的瘢痕硬度和间质液缓慢转移有关。
