Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School.
The Yvonne L. Munn Center for Nursing Research, Massachusetts General Hospital, Boston.
J Infect Dis. 2020 Feb 3;221(4):510-515. doi: 10.1093/infdis/jiz254.
Interleukin 10 (IL-10) is an anti-inflammatory cytokine that may be protective against coronary atherosclerosis. In an observational study of persons with human immunodeficiency virus (PWH) and uninfected controls, IL-10 was measured in serum samples by means of enzyme-linked immunosorbent assay, and coronary atherosclerosis was assessed using computed tomographic angiography. Among PWH, a 10-fold decrease in IL-10 was associated with a 2.6-fold increase in the odds of coronary plaque (P = .01), after controlling for traditional and nontraditional cardiovascular risk factors. IL-10 was also inversely associated with total coronary plaque (ρ = -0.19; P = .02) and noncalcified coronary plaque (ρ = -0.24; P = .004). Our findings suggest a role for IL-10 in mitigating atherosclerosis in PWH. Clinical Trials Registration. NCT00455793.
白细胞介素 10（IL-10）是一种抗炎细胞因子，可能对冠状动脉粥样硬化具有保护作用。在一项针对人类免疫缺陷病毒（HIV）感染者和未感染者的观察性研究中，通过酶联免疫吸附试验检测血清样本中的 IL-10，通过计算机断层血管造影评估冠状动脉粥样硬化。在 HIV 感染者中，在控制传统和非传统心血管危险因素后，IL-10 降低 10 倍与冠状动脉斑块形成的几率增加 2.6 倍相关（P =.01）。IL-10 还与总冠状动脉斑块呈负相关（ρ = -0.19；P =.02）和非钙化冠状动脉斑块呈负相关（ρ = -0.24；P =.004）。我们的研究结果表明 IL-10 在减轻 HIV 感染者的动脉粥样硬化方面发挥作用。临床试验注册。NCT00455793。
