Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Urology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Nephrol Dial Transplant. 2020 Aug 1;35(8):1306-1316. doi: 10.1093/ndt/gfz054.
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst formation, leading to growth in kidney volume and renal function decline. Although therapies have emerged, there is still an important unmet need for slowing the rate of disease progression in ADPKD. High intracellular levels of adenosine 3',5'-cyclic monophosphate (cAMP) are involved in cell proliferation and fluid secretion, resulting in cyst formation. Somatostatin (SST), a hormone that is involved in many cell processes, has the ability to inhibit intracellular cAMP production. However, SST itself has limited therapeutic potential since it is rapidly eliminated in vivo. Therefore analogues have been synthesized, which have a longer half-life and may be promising agents in the treatment of ADPKD. This review provides an overview of the complex physiological effects of SST, in particular renal, and the potential therapeutic role of SST analogues in ADPKD.
常染色体显性多囊肾病（ADPKD）的特征是进行性囊肿形成，导致肾脏体积增大和肾功能下降。尽管已经出现了一些治疗方法，但减缓 ADPKD 疾病进展速度的需求仍然很大。细胞内高水平的腺苷 3'，5'-环单磷酸（cAMP）参与细胞增殖和液体分泌，导致囊肿形成。生长抑素（SST）是一种参与多种细胞过程的激素，具有抑制细胞内 cAMP 产生的能力。然而，SST 本身的治疗潜力有限，因为它在体内会迅速被清除。因此，已经合成了类似物，它们具有更长的半衰期，可能是治疗 ADPKD 的有前途的药物。这篇综述概述了 SST 的复杂生理作用，特别是在肾脏方面，以及 SST 类似物在 ADPKD 中的潜在治疗作用。
