Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, Messina, Italy.
IRCCS Centro Neurolesi "Bonino Pulejo", Messina, Italy.
Mov Disord. 2019 Jul;34(7):987-996. doi: 10.1002/mds.27712. Epub 2019 May 11.
Understanding the topographical organization of the cortico-basal ganglia circuitry is of pivotal importance because of the spreading of techniques such as DBS and, more recently, MR-guided focused ultrasound for the treatment of movement disorders. A growing body of evidence has described both direct cortico- and dento-pallidal connections, although the topographical organization in vivo of these pathways in the human brain has never been reported.
To investigate the topographical organization of cortico- and dento-pallidal pathways by means of diffusion MRI tractography and connectivity based parcellation.
High-quality data from 100 healthy subjects from the Human Connectome Project repository were utilized. Constrained spherical deconvolution-based tractography was used to reconstruct structural cortico- and dento-pallidal connectivity. Connectivity-based parcellation was performed with a hypothesis-driven approach at three different levels: functional regions (limbic, associative, sensorimotor, and other), lobes, and gyral subareas.
External globus pallidus segregated into a ventral associative cluster, a dorsal sensorimotor cluster, and a caudal "other" cluster on the base of its cortical connectivity. Dento-pallidal connections clustered only in the internal globus pallidus, where also associative and sensorimotor clusters were identified. Lobar parcellation revealed the presence in the external globus pallidus of dissociable clusters for each cortical lobe (frontal, parietal, temporal, and occipital), whereas in internal globus pallidus only frontal and parietal clusters were found out.
We mapped the topographical organization of both internal and external globus pallidus according to cortical and cerebellar connections. These anatomical data could be useful in DBS, radiosurgery and MR-guided focused ultrasound targeting for treating motor and nonmotor symptoms in movement disorders. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
理解皮质基底节回路的拓扑组织至关重要，因为诸如 DBS 等技术的传播，以及最近用于治疗运动障碍的磁共振引导聚焦超声技术。越来越多的证据描述了皮质和齿状苍白球的直接连接，尽管这些通路在人类大脑中的体内拓扑组织从未被报道过。
通过扩散 MRI 束追踪和基于连接的分割来研究皮质和齿状苍白球通路的拓扑组织。
利用来自人类连接组计划存储库的 100 名健康受试者的高质量数据。使用基于约束球分解的束追踪技术来重建结构皮质和齿状苍白球的连接。基于连接的分割采用假设驱动的方法在三个不同的水平上进行：功能区域（边缘、联合、感觉运动和其他）、叶和回区亚区。
外部苍白球根据其皮质连接分为腹侧联合簇、背侧感觉运动簇和尾侧“其他”簇。齿状苍白球的连接仅在内部苍白球中聚集，在内部苍白球中还确定了联合和感觉运动簇。叶区分割显示，外部苍白球中每个皮质叶（额、顶、颞和枕叶）都存在可分离的簇，而在内部苍白球中仅发现了额叶和顶叶簇。
我们根据皮质和小脑的连接描绘了内外苍白球的拓扑组织。这些解剖学数据可用于 DBS、放射外科和磁共振引导聚焦超声靶向治疗运动和非运动障碍的症状。© 2019 作者。运动障碍由 Wiley 期刊出版公司代表国际帕金森病和运动障碍协会出版。
