Terashima T, Katada T, Oinuma M, Inoue Y, Ui M
Brain Res. 1987 Apr 28;410(1):97-100. doi: 10.1016/s0006-8993(87)80026-4.
The localization of a guanine nucleotide-binding protein, Go, in rat retina has been immunohistochemically examined by use of affinity-purified antibody against the alpha-subunit of Go. Dense Go-immunoreactive products are localized in the inner and outer plexiform layers which are considered as the region of synaptic interplay between neuronal components of the retina. Weak Go-immunoreactivity is also found in the neuropil of the ganglion cell layer and the inner nuclear layer. The selective enrichment of Go in synaptic zones of the retina suggests its major role in neuronal transmission within the retina.
利用针对Goα亚基的亲和纯化抗体，通过免疫组织化学方法检测了鸟嘌呤核苷酸结合蛋白Go在大鼠视网膜中的定位。密集的Go免疫反应产物定位于内、外丛状层，这两层被认为是视网膜神经元成分之间突触相互作用的区域。在神经节细胞层和内核层的神经毡中也发现了较弱的Go免疫反应性。Go在视网膜突触区的选择性富集表明其在视网膜内神经元传递中起主要作用。
