可溶性神经细胞黏附分子与经颅直流电刺激治疗最小意识状态患者的行为恢复
Soluble neural cell adhesion molecule and behavioural recovery in minimally conscious patients undergoing transcranial direct current stimulation.
机构信息
Department of Life Science and Biotechnology, University of Ferrara, Italy.
Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Italy.
出版信息
Clin Chim Acta. 2019 Aug;495:374-376. doi: 10.1016/j.cca.2019.05.008. Epub 2019 May 8.
BACKGROUND
Transcranial direct current stimulation (tDCS) is used for therapeutic purpose in severely brain-injured patients. The relationship between the recovery after tDCS and potential biomarkers in plasma has been limitedly investigated in patients with minimal conscious state (MCS).
OBJECTIVE
To investigate soluble neuronal adhesion molecule (sNCAM) plasma levels in relation to tDCS and recovery processes in MCS.
METHODS
sNCAM was measured in plasma before (T,T), during (T) and after (T T) tDCS sessions in eight patients with a post traumatic etiology and at least one year of chronic state.
RESULTS
While sNCAM levels were highly correlated overtime, no significant difference was observed in relation to tDCS. An inverse relation was observed between sNCAM levels at baseline and the tDCS long-lasting effects (T, r = -0.852, p = 0.007; T, r = -0.787, p = 0.020).
CONCLUSIONS
This exploratory research suggests the sNCAM levels, potentially associated with tDCS outcomes, as a candidate biomarker of neurobiological after-effects in MCS patients.
背景
经颅直流电刺激（tDCS）被用于治疗严重脑损伤患者。在最小意识状态（MCS）患者中，tDCS 后恢复与潜在血浆生物标志物之间的关系仅得到有限的研究。
目的
探讨与 tDCS 及 MCS 恢复过程相关的血浆可溶性神经元黏附分子（sNCAM）水平。
方法
对 8 例创伤性病因且慢性状态至少 1 年的患者，在 tDCS 治疗前后（T、T、T T）测量血浆 sNCAM。
结果
sNCAM 水平随时间高度相关，但与 tDCS 无关。基线 sNCAM 水平与 tDCS 长期效应呈负相关（T，r=-0.852，p=0.007；T，r=-0.787，p=0.020）。
结论
这项探索性研究表明，sNCAM 水平可能与 tDCS 结果相关，是 MCS 患者神经生物学后效的候选生物标志物。
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