Research Center for Psychiatry and Behavior Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Epilepsy Res. 2019 Aug;154:74-76. doi: 10.1016/j.eplepsyres.2019.05.001. Epub 2019 May 2.
This study aimed to investigate the effects of sigma receptor modulators, opipramol and BD-1063, on epileptogenesis in pentylenetetrazole (PTZ)-kindling model of epilepsy. Mice (n = 6/group) were received PTZ (30 mg/kg), PTZ plus opipramol (5 or 10 mg/kg), PTZ plus opipramol (5 mg/kg) plus BD-1063 (5 mg/kg, a selective sigma-1 receptor antagonist), and PTZ plus BD-1063 on alternate days for 15 days. Opipramol (5 and 10 mg/kg) + PTZ groups became fully kindled and had higher seizure scores compared to the PTZ group. In contrast, the PTZ plus BD-1063 and the PTZ plus opipramol (5 mg/kg) plus BD-1063 group did not show full kindling. These findings indicate that opipramol has a pro-convulsant effect, which is possibly mediated through activation of sigma-1 receptors.
本研究旨在探讨 sigma 受体调节剂奥匹哌醇和 BD-1063 对戊四氮（PTZ）点燃癫痫模型癫痫发生的影响。小鼠（n=6/组）接受 PTZ（30mg/kg）、PTZ 加奥匹哌醇（5 或 10mg/kg）、PTZ 加奥匹哌醇（5mg/kg）加 BD-1063（5mg/kg，一种选择性 sigma-1 受体拮抗剂），以及隔日接受 PTZ 加 BD-1063 治疗，共 15 天。奥匹哌醇（5 和 10mg/kg）+PTZ 组完全点燃，与 PTZ 组相比，发作评分更高。相比之下，PTZ 加 BD-1063 组和 PTZ 加奥匹哌醇（5mg/kg）加 BD-1063 组未出现完全点燃。这些发现表明奥匹哌醇具有促惊厥作用，可能通过激活 sigma-1 受体介导。
