Fass R J, Helsel V L
Diagn Microbiol Infect Dis. 1987 Apr;6(4):293-9. doi: 10.1016/0732-8893(87)90178-7.
The in vitro activities of RO 23-6240 (AM-833) and four comparative fluoroquinolones were studied. Minimal inhibitory concentrations (MICs) of RO 23-6240, which inhibited at least 90% of strains, were less than or equal to 0.03-1 microgram/ml for Staphylococcus aureus, Staphylococcus epidermidis, Enterobacteriaceae, Acinetobacter anitratus Aeromonas hydrophila, Branhamella catarrhalis, and Haemophilus influenzae, 2-8 micrograms/ml for Staphylococcus saprophyticus, streptococci, diphtheroids, and Pseudomonas spp., and 1-32 micrograms/ml for anaerobic species. MICs of ofloxacin, pefloxacin, norfloxacin, and ciprofloxacin paralleled those of RO 23-6240. With all five drugs, MICs were minimally affected by inoculum size and minimal bacterial concentrations (MBCs) were always within two dilution steps (log2) of MICs.
对RO 23 - 6240（AM - 833）和四种对照氟喹诺酮类药物的体外活性进行了研究。RO 23 - 6240对至少90%菌株具有抑制作用，其对金黄色葡萄球菌、表皮葡萄球菌、肠杆菌科细菌、鲍氏不动杆菌、嗜水气单胞菌、卡他布兰汉菌和流感嗜血杆菌的最低抑菌浓度（MIC）小于或等于0.03 - 1微克/毫升，对腐生葡萄球菌、链球菌、类白喉杆菌和假单胞菌属的MIC为2 - 8微克/毫升，对厌氧菌的MIC为1 - 32微克/毫升。氧氟沙星、培氟沙星、诺氟沙星和环丙沙星的MIC与RO 23 - 6240的MIC相似。对于所有这五种药物，接种量对MIC的影响极小，且最小杀菌浓度（MBC）始终在MIC的两个稀释步骤（log2）范围内。
