Department of Medicine (Endocrinology), Medical College of Wisconsin, Milwaukee, WI, USA.
Department of Medicine (Endocrinology), University of Wisconsin School of Medicine, Madison, WI, USA.
Osteoporos Int. 2019 Aug;30(8):1699-1703. doi: 10.1007/s00198-019-04998-5. Epub 2019 May 11.
We report a 46-yr-old woman with a history of breast cancer who presented with diffuse myalgias, bone pain, and osteosclerosis. She was found to have recurrent breast cancer producing endothelin-1.
Acquired osteosclerosis can be caused by various disorders. Endothelin -1 is believed to contribute to osteosclerosis caused by breast cancer.
Although the bone marrow biopsy did not reveal breast cancer, she developed skin lesions consistent with metastatic breast cancer. She ultimately died from progressive disease. At autopsy immunohistochemistry for endothelin-1 was performed on a section from the L5 vertebral body.
The section from the L5 vertebral body showed small foci of cells consistent with metastatic carcinoma and a prominent sclerotic response. Immunohistochemistry for endothelin-1 was strongly positive.
Recurrent breast cancer may present with diffuse osteosclerosis. Endothelin-1 may be a paracrine factor responsible for increased bone formation and osteosclerosis.
我们报告了一位 46 岁的女性乳腺癌病史患者，她表现为弥漫性肌肉疼痛、骨痛和骨硬化。发现她患有复发性产生内皮素-1 的乳腺癌。
获得性骨硬化症可由各种疾病引起。内皮素-1 被认为有助于乳腺癌引起的骨硬化症。
尽管骨髓活检未发现乳腺癌，但她出现了符合转移性乳腺癌的皮肤病变。她最终死于进行性疾病。尸检时，在 L5 椎体的切片上进行了内皮素-1 的免疫组织化学检查。
L5 椎体的切片显示小灶状细胞符合转移性癌和明显的硬化反应。内皮素-1 的免疫组织化学检查呈强阳性。
复发性乳腺癌可能表现为弥漫性骨硬化症。内皮素-1 可能是一种旁分泌因子，负责增加骨形成和骨硬化症。
