College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Xin Mofan Road 5, Nanjing, 210009, China.
National Engineering Technique Research Center for Biotechnology, Nanjing, China.
Bioprocess Biosyst Eng. 2019 Sep;42(9):1435-1445. doi: 10.1007/s00449-019-02140-7. Epub 2019 May 11.
Vanillin and syringaldehyde are widely used as flavoring and fragrance agents in the food products. The potential of a macro-mesoporous adsorption resin was assessed for separation of these binary mixtures. This work focuses on modeling of the competitive adsorption behaviors and exploration of the adsorption mechanism. The characterization results showed the resin had a large BET surface area and specific pore structure with hydrophobic properties. By analysis of the physicochemical properties of the solutes and the resin, the separation mechanism was mainly contributed by hydrophobic effect. Subsequently, the competitive Langmuir isotherm model was used to fit the competitive adsorption isotherms. The pore diffusion coefficient was obtained by macropore diffusion model. Afterwards, a mathematical model was established to predict the breakthrough curves of the binary mixture at various operating conditions. The data and model presented are valuable for design and simulation of the continuous chromatographic separation process.
香草醛和苯甲醛作为食用香精广泛应用于食品产品中。本文评估了一种大孔-介孔吸附树脂对该二元混合物的分离性能。本文重点研究了二元混合物竞争吸附行为的模拟和吸附机理的探讨。结果表明，树脂具有较大的比表面积和特定的介孔结构，同时具有疏水性。通过对溶质和树脂理化性质的分析，分离机制主要归因于疏水作用。随后，采用竞争 Langmuir 等温吸附模型对竞争吸附等温线进行拟合，通过大孔扩散模型得到孔扩散系数。最后，建立了一个数学模型来预测在不同操作条件下二元混合物的穿透曲线。所提供的数据和模型对于连续色谱分离过程的设计和模拟具有重要价值。
