抗惊厥药对低频刺激诱发的杏仁核点燃性癫痫发作的急性作用。

Acute effect of anticonvulsants on amygdaloid kindled seizures induced with low-frequency stimulations.

作者信息

Minabe Y, Tanii Y, Kurachi M

出版信息

Epilepsia. 1987 May-Jun;28(3):222-7. doi: 10.1111/j.1528-1157.1987.tb04211.x.

DOI:10.1111/j.1528-1157.1987.tb04211.x

Abstract

Acute effects of several antiepileptic drugs on low-frequency amygdaloid-kindled seizures were assessed. The number of stimulating pulses required for the provocation of epileptic afterdischarge (pulse-number threshold, PNT) was used as an indicator for the seizure-generating threshold. The duration of epileptic afterdischarge (AD duration) was used as an indicator for the severity of the induced seizures. Phenytoin (PHT) and carbamazepine (CBZ) reduced AD duration more than did elevating PNT. Conversely, phenobarbital (PB) and diazepam (DZP) elevated PNT more than did reducing AD duration. Weak effects on the two indicators, valproic acid (VPA) and ethosuximide (ESM), were observed. Low-frequency kindling may be a useful experimental model of epilepsy in drug-assessments.

摘要

评估了几种抗癫痫药物对低频杏仁核点燃性癫痫发作的急性效应。诱发癫痫后放电所需的刺激脉冲数（脉冲数阈值，PNT）被用作癫痫发作产生阈值的指标。癫痫后放电的持续时间（AD持续时间）被用作诱发癫痫发作严重程度的指标。苯妥英（PHT）和卡马西平（CBZ）降低AD持续时间的作用比提高PNT的作用更明显。相反，苯巴比妥（PB）和地西泮（DZP）提高PNT的作用比降低AD持续时间的作用更明显。观察到丙戊酸（VPA）和乙琥胺（ESM）对这两个指标的作用较弱。低频点燃可能是药物评估中一种有用的癫痫实验模型。